Endocrine Abstracts

Purpose: D631Y is a rare mutation associated with MEN2a in which there is an aspartic acid to tyrosine amino acid substitution at codon 631 in exon 11. Common clinical features of this variant of RET mutation are pheochromocytoma in 50%, medullary carcinoma in 30%, primary hyperparathyroidism is very rare. We present the patient harboring RET D631Y mutation.Clinical case: In April 2017 40-year-old woman was admitted to endocrine department of the Almazov...

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge in the management of patients with Cushing’s disease. There are some data on the possibility of pituitary adenomas to accumulate 18F-fluorodeoxyglucose (18F-FDG) during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT).Aim: To study the potential of brain 18F-fluorodeoxyglucose PET/CT for localization of MRI-negative ACTH-producing ...

Introduction: Perioperative assessment of surgical outcome in acromegaly patients is essential due to significant persistence rate even after total adenomectomy. Grade of adenoma invasiveness and basal growth hormone (GH) level in early postoperative period have been considered as important factors.Aim: The aim of our study was to evaluate the correlation between the outcomes of surgery in patients with acromegaly and the grade of adenoma invasion assess...

Purpose: According to modern guidelines late night serum cortisol measurement is not considered to be among the first steps for screening of hypercortisolism. But in some cases it may be useful as it allows identifying the loss of normal circadian rhythm of cortisol secretion. This test is not rarely used in hospitalized patients when Cushing’s syndrome is suspected. But the cutt-off point of nighttime serum cortisol level for the diagnosis of hypercortisolism is inconsis...

Introduction: Transsphenoidal surgery (TSS) is the treatment of choice for patients with acromegaly. However, even after radical surgery persistence of acromegaly may remain up to thirty percent by resent studies (Starnoni, 2016). Nadir growth hormone (GH) level less than 1.0 μg/l on an early postoperative oral glucose tolerance test (OGTT) have been suggested as early predictor of surgical remission (Kim 2012). However, the value of this approach remains to be defined.</...

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). Persistence and recurrence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) in the prognosis of CD remission after TSS.Materials and methods: 60 patients with Cus...

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). However, persistence and recurrence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) and pituitary MRI in the prognosis of CD remission after TSS.Materials and me...

Introduction: Acromegaly is a chronic disorder caused by growth hormone (GH) hyperproduction which leads to significant morbidity and mortality primarily due to cardiovascular and respiratory complications. Pituitary adenoma is the main cause of GH’s hyperproduction. By current guidelines transsphenoidal surgery (TSS) is the first-line treatment in acromegaly patients.Aim: To evaluate the results of TSS in acromegaly patients 6 months after surgery....

Introduction: Growth hormone (GH) level is a direct marker of active residual adenoma tissue after acromegaly surgery. However, the value of early postoperative GH for prediction of surgical cure in acromegaly has not been established and therefore is not used in everyday clinical practice.Aim: The aim of our work was to study the 24-hour basal postoperative GH level and the nadir of GH level after the oral glucose tolerance test (OGTT) two weeks after s...

Introduction: Prolactinomas are the most common pituitary adenomas. Dopamine agonists (DAs) are the treatment of choice for prolactinomas. Patients with prolactinomas normally are treated in ambulatory. In some patients there are challenges in therapy, and they need to be hospitalized.Objective: To study the clinical features and outcomes of in-patients with prolactinoma.Materials and methods: A retrospective analysis of 40 hospita...